Directions: Locate three peer reviewed,
empirical articles related to the potential broad topic area of your
dissertation. Remember, your topic area must align with your degree
program. Select only articles that have been published within the last
2-3 years and that could logically be included in the literature review
of your dissertation. (attached on literature review)Write a brief description of the articles (250-300 words total) that includes the following information for each article:A statement of what the authors studied.A statement that generally describes the study participants.A description of the study findings.A statement of one limitation or future study idea identified in the article.Write an argument (250-500 words) that presents a potential study topic for your dissertation and defends the need for the potential study. The topic must emerge from a synthesis of the limitations or future study ideas you identified above, and the argument must describe how the potential study might address the synthesized limitations or future study ideas.Requires doctoral writing, APA 6th edition required. Must include in-text citations and reference page- references are already included in this assignment on the attached document.College of Doctoral Studies
PSY-802 Literature Review Resources
N Article Information
u
m
be
r
1.Bibliographic Information
Bibbo, G., Kirkwood, I., Sigalas, V., & Benger, T. (2019). Radioiodine (131I)
therapy in a child with autism spectrum disorder: A complex and demanding task.
World Journal of Nuclear Medicine, 18(3), 293–295. https://doiorg.lopes.idm.oclc.org/10.4103/wjnm.WJNM_40_18
Link
https://lopes.idm.oclc.org/login?url=https://search.ebscohost.com/login.aspx?direct
=true&db=a9h&AN=138126252&site=eds-live&scope=site
Annotation
Study was completed on an 11-year-old male with the diagnosis of autism. The
child was initially referred for radioiodine therapy also known as RAI. The child
was studied to determine if a 48-72 hour isolation would result in him swallowing a
RAI capsule. Barriers for the patient were his behavioral issues related to his
autism, mild I/DD (intellectual developmental disability), and his parental
environment. His mother was convinced he would not swallow and the capsule or
be agreeable with the isolation time period. As a result, a multidisciplinary team
was developed in order to aid in his successful treatment. Several options were
considered such as regular, frequent contact between the child, his parents, and
members of the team for counseling and behavioral modification, familiarization of
the child with the staff, procedures, trial visits, and admission. The team determined
behavioral therapy to be the only possible option. As a result, the patient was
successful in his treatment.
Bibliographic Information
Ad
de
d
to
Ref
Wo
rks
? (Y
or
N)
Y
2.Dae-Wook Kang, James B. Adams, Devon M. Coleman, Elena L. Pollard, Juan
Y
Maldonado, Sharon McDonough-Means,Rosa Krajmalnik-Brown. (2019). Longterm benefit of Microbiota Transfer Therapy on autism symptoms and gut
microbiota. Scientific Reports, (1), 1. https://doiorg.lopes.idm.oclc.org/10.1038/s41598-019-42183-0
Link
https://lopes.idm.oclc.org/login?url=https://search.ebscohost.com/login.aspx?direct
=true&db=edsdoj&AN=edsdoj.5d6b1a5e6b9048b5bb0b45a90b020b30&site=edslive&scope=site
Annotation
Historically, there has been several studies completed that report abnormal gut
microbiota in people with autism. In these studies it has been suggested that there is
a link between autism and gut microbiome. As a result, study was completed
utilizing open-label trials of microbiota transfer therapy otherwise known as MTT.
This study combined antibiotics, bowel cleansing, stomach acid suppressants and
fecal microbiota transplant from a healthy microbiota donor. In the study 18
participants were involved. Follow-up 2 years after their treatments showed
positive results. Gastrointestinal symptoms as well as microbiota were maintained
over this time frame. In addition, autism related symptoms also showed
improvement. During these observations is was determined that MTT not only was
very effective but also showed long-term effects and safety as a future therapy to
treat autism who also have gastrointestinal issues.
3.Bibliographic Information
Gilles Maussion, Cecilia Rocha, Geneviève Bernard, Lenore K. Beitel, & Thomas
M. Durcan. (2019). Patient-Derived Stem Cells, Another in vitro Model, or the
Missing Link Toward Novel Therapies for Autism Spectrum Disorders? Frontiers
in Pediatrics. https://doi-org.lopes.idm.oclc.org/10.3389/fped.2019.00225
Link
https://lopes.idm.oclc.org/login?url=https://search.ebscohost.com/login.aspx?direct
=true&db=edsdoj&AN=edsdoj.41bdae787a2840d79db99cbbaa92c526&site=edslive&scope=site
© 2014. Grand Canyon University. All Rights Reserved.
Y
Annotation
Autism is known historically as a multigenic, multi-factorial, and neuro
developmental disorder that is typically diagnosed in early childhood. Autism leads
to deficits in social skills, verbal and non-verbal communication. In addition,
autism is characterized by restricted and repetitive behaviors and interests. In order
to understand the genetic, descriptive and mechanistic aspects of autism, several
studies have been conducted. Mouse models and postmortem brain tissue have also
been studied in order to better understand and treat autism. Today, the technology
to now generate stem cells from patient samples has brought breakthrough for
autism through 2D and 3D neuronal models. The goal is to build new therapeutic
strategies for treatment. Through these studies of mouse models and human
samples advancement in the knowledge and pathophysiology of autism can be
discovered. Thus, considering the complexities of these disorders, patient-derived
models have immense potential to clarify molecular deregulation that contributed to
the different autistic phenotype. Through these direct investigations with the human
in vitro models, they offer the potential for opening new therapeutic avenues.
4.Bibliographic Information
Ruu-Fen Tzang, Chuan-Hsin Chang, Yue-Cune Chang, & Hsien-Yuan Lane.
(2019). Autism Associated With Anti-NMDAR Encephalitis: Glutamate-Related
Therapy. Frontiers in Psychiatry. https://doiorg.lopes.idm.oclc.org/10.3389/fpsyt.2019.00440
Link
https://lopes.idm.oclc.org/login?url=https://search.ebscohost.com/login.aspx?direct
=true&db=edsdoj&AN=edsdoj.f48fec59c339441d95e7ebc5017038d2&site=edslive&scope=site
Annotation
This study was conducted to determine if autism is in fact associated with
autoimmune dysfunction. There are several auto antibodies that can cause
psychiatric symptoms such as hallucinations, psychosis, behavioral changes and so
on. The auto antibody binds to certain brain receptors which cause the neuro
transmission in the brain to manifest these symptoms. During the study there was
detection of these auto antibodies affecting several imbalances in the blood. In
addition several infections were noted in the patients’ history. The child’s medical
history and lab reports show significant signs of auto immune autism. It is
determined in the study that early detection of these autoimmune encephalitis can
potentially increase the effects of the treatments. With the aid of these treatments
© 2014. Grand Canyon University. All Rights Reserved.
Y
the symptoms that are resulted from the antibodies could be minimized or
eliminated completely. This study has concluded that immune therapies could
potentially prevent long-term effects for auto immune autism. Findings in the
study show glutamate therapy is most effective in bringing the neuro transmitters
back to normal range, in addition to being an additional intervention to medication
for treatment.
5.Bibliographic Information
Y
Stephanie Saaybi, Natally AlArab, Salem Hannoun, Maritherese Saade, Rayyan
Tutunji, Carine Zeeni, … Rose-Mary Boustany. (2019). Pre- and Post-therapy
Assessment of Clinical Outcomes and White Matter Integrity in Autism Spectrum
Disorder: Pilot Study. Frontiers in Neurology. https://doiorg.lopes.idm.oclc.org/10.3389/fneur.2019.00877
Link
https://lopes.idm.oclc.org/login?url=https://search.ebscohost.com/login.aspx?direct
=true&db=edsdoj&AN=edsdoj.84a0393a5d64ea5aba51c3340f1b869&site=edslive&scope=site
Annotation
This study was conducted to determine if diffusion tensor imaging (DTI) can
identify white matter tract abnormalities in autism. MRI was conducted to gather
baseline results in order to compare results after the study to determine
improvement or no changes. The study was completed on toddlers and
preschoolers who have been diagnosed with autism. Image findings with clinical
improvement were compared after early interventions as well as, applied behavior
analysis (ABA) therapy by verbal behavior milestones assessments. Placement
program methods were also completed utilizing DTI scans. These studies were
completed on a total of 17 toddlers with autism diagnoses. DTI findings showed
that autism patients’ white matter abnormalities showed benefits of the early
interventions and ABA therapy on clinical and imaging outcomes.
6.Bibliographic Information
Benger, M., Kinali, M., & Mazarakis, N. D. (2018). Autism spectrum disorder:
Prospects for treatment using gene therapy. Molecular Autism, (1), 1.
doi:10.1186/s13229-018-0222-8
© 2014. Grand Canyon University. All Rights Reserved.
Y
Link
https://lopes.idm.oclc.org/login?url=https://search.ebscohost.com/login.aspx?direct=tru
e&db=a9h&bquery=IS+20402392+AND+TI+(%26quot%3bAutism+spectrum+disorder%3a+prospects+for+treatment+u
sing+gene+therapy%26quot%3b)+AND+DT+%26quot%3b2018%26quot%3b+AND+AU+%2
6quot%3bBenger%26quot%3b&cli0=FT&clv0=Y&type=1&searchMode=Standard&site=eh
ost-live&scope=site
Annotation
In this study gene replacement therapy is performed in patients with Autism
Spectrum disorder (ASD) This study was completed over a period of five years.
gene therapy offers a promising alternative to conventional small molecule
therapies. Preclinical studies over the last 5 years using animal models displaying
autism-like traits have demonstrated that directly altering gene expression using
rAAV-delivered transgenes can reverse the behavioral phenotype, either via gene
replacement or RNA knockdown. Such studies establish proof-of-concept and set
up a platform for clinical translation in various monogenic ASDs, with RS being a
frontrunner in this regard. However, there is still much more research and barriers
to gene therapy that need to be overcome first before this therapy can be offered to
the public. There are many factors that need to be considered first such as
hereditary factors which was explored some in this case study.
7.Bibliographic Information
Caputo, G., Ippolito, G., Mazzotta, M., Sentenza, L., Muzio, M. R., Salzano, S., &
Conson, M. (2018). Effectiveness of a multisystem aquatic therapy for children
with autism spectrum disorders. Journal of Autism & Developmental Disorders,
48(6), 1945-1956. doi:10.1007/s10803-017-3456-y
Link
https://lopes.idm.oclc.org/login?url=https://search.ebscohost.com/login.aspx?direct=tru
e&db=ccm&AN=129572139&site=ehost-live&scope=site
Annotation
This study tested to see is aqua therapy would be a form of successful treatment
for children with Autism Spectrum Disorder. Aqua therapy has been successful in
other illnesses and disabilities to improve overall motor skills and improving
injuries. It has been believed that aqua therapy would also be successful in
improving the motor skills in children with Autism Spectrum disorder prior to this
study. In this study it the effectiveness of a multisystem aquatic therapy on
© 2014. Grand Canyon University. All Rights Reserved.
Y
behavioral, emotional, social and swimming skills of children with Autism
Spectrum Disorder was tested. Multisystem aquatic therapy was divided in three
phases: emotional adaptation, swimming adaptation and social integration. This
study was over a ten-month program. Following this study the aqua therapy group
showed definitive evidence of improvements relative to controls on functional
adaptation (Vineland Adaptive Behavior Scales), emotional response, adaptation
to change and on activity level (Childhood Autism Rating Scale). Swimming skills
learning was also demonstrated. Multisystem aquatic therapy is useful for
ameliorating functional impairments of children with Autism Spectrum Disorder,
going well beyond a swimming training.
8.Bibliographic Information
DiPietro, J., Kelemen, A., Liang, Y., & Cecilia Sik-Lanyi. (2019). Computer- and
robot-assisted therapies to aid social and intellectual functioning of children with
autism spectrum disorder. Medicina, (8), 440. doi:10.3390/medicina55080440
Link
https://eds-b-ebscohost-com.lopes.idm.oclc.org/eds/detail/detail?vid=0&sid=dce689a6d4fe-46ad-97f40b7fd0e6cdf7%40sessionmgr102&bdata=JnNpdGU9ZWRzLWxpdmUmc2NvcGU9c2l0ZQ%
3d%3d#AN=edsdoj.695bdc3e304f47768f399b9f96dc4a0b&db=edsdoj
Annotation
Children with autism spectrum disorder (ASD) experience challenges with social
interactions, a core feature of the disorder. Social skills therapy has been shown to
be helpful. Over the past several years, computer-assisted and robot-assisted
therapies have been infiltrating the social skills teaching environment. Rapid
progress in the field of technology, especially in the robotics area, offers
tremendous possibilities for innovation and treatment or even education for
individuals with ASD. The purpose of this study is to drive awareness of these
innovative interventions in order to support the social lives of children with ASD.
The goals of this study are identifying the types of Information Technology
platforms that are being evaluated in computer and robot-assisted therapies for
children with ASD; the various disciplines or professions studying and utilizing
these computer and robot-assisted social skill therapies; the outcomes being
evaluated in each trial; and if results demonstrate benefits to children with
autism.
Bibliographic Information
© 2014. Grand Canyon University. All Rights Reserved.
Y
9.Kaur, K. S., & Pathak, R. (2019). Play-based occupational therapy intervention on
Y
social skills in children with autism spectrum disorder and attention deficit
hyperactivity disorder: A case series. Indian Journal of Occupational Therapy,
51(1), 31-36. doi:10.4103/ijoth.ijoth_5_19
Link
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e&db=a9h&AN=136066647&site=ehost-live&scope=site
Annotation
This study focuses on the social aspect of children. In children who have Autism Spectrum
disorder the social aspect is one that is very difficult for children with ASD. Often children
with ASD do not know how to interact with their peers and are award in social settings.
This presents a great deal of issues for them going into adulthood. In addition, due to the
lack of their abilities to act appropriately in social settings many limits are set for children
with ASD and this can also cause further anxiety, depression and behavioral problems.
This study was completed in kids 4-5 years of age with a diagnosis of ASD. Data was
collected prior to starting this study to determine social skills level before and after. Play
was incorporated in occupational therapy in sessions that were completed twice a week
for sixty minutes. After six months the data was reviewed which showed progress was
made in social skills.
1 Bibliographic Information
0
Kenny, D. T. (2019). Faulty theory, failed therapy: Frances tustin, infant and child
psychoanalysis, and the treatment of autism spectrum disorders. SAGE Open,
doi:10.1177/2158244019832686
Link
https://eds-a-ebscohostcom.lopes.idm.oclc.org/eds/detail/detail?vid=0&sid=f784aeda-d840-4f4e-a0ae587913452871%40sessionmgr4007&bdata=JnNpdGU9ZWRzLWxpdmUmc2NvcGU
9c2l0ZQ%3d%3d#AN=edsdoj.7a81b1373c9a4ec4a02edbea724d376a&db=edsdoj
Annotation
This study focuses on infants and the treatment of autism. The infant and child
psychoanalysis expounded and developmental psychology and developmental
neuroscience. There are two issues in this study that are examined; How early
© 2014. Grand Canyon University. All Rights Reserved.
Y
psychoanalytic insights informed empirical developments and theoretical
scholarship in both infant psychoanalysis and developmental psychology, and how
the study of infant development within psychoanalysis has been derailed by faulty
theorizing and failure to incorporate scientific scholarship on infant development
into their theories and practice. There is review current research on infancy
including psychoanalytic contributions that have incorporated scientific methods
and evidence. The author also worked with Frances Tustin’s theory of autism as an
exemplar of the problematic theorizing about infant development that remains
unchallenged, even today, in some psychoanalytic circles, and how that theory is
operationalized in treatment.
References
Bibbo, G., Kirkwood, I., Sigalas, V., & Benger, T. (2019). Radioiodine (131I) therapy in a child
with autism spectrum disorder: A complex and demanding task. World Journal of Nuclear
Medicine, 18(3), 293-295. doi:10.4103/wjnm.WJNM_40_18
Dae-Wook Kang, Adams, J. B., Coleman, D. M., Pollard, E. L., Maldonado, J., Sharon
McDonough-Means, . . . Rosa Krajmalnik-Brown. (2019). Long-term benefit of microbiota
transfer therapy on autism symptoms and gut microbiota. Scientific Reports, (1), 1.
doi:10.1038/s41598-019-42183-0
Maussion, G., Rocha, C., Geneviève Bernard, Beitel, L. K., & Durcan, T. M. (2019). Patientderived stem cells, another in vitro model, or the missing link toward novel therapies for
autism spectrum disorders? Frontiers in Pediatrics, doi:10.3389/fped.2019.00225
Ruu-Fen Tzang, Chuan-Hsin Chang, Yue-Cune Chang, & Hsien-Yuan Lane. (2019). Autism
associated with anti-NMDAR encephalitis: Glutamate-related therapy. Frontiers in
Psychiatry, doi:10.3389/fpsyt.2019.00440
© 2014. Grand Canyon University. All Rights Reserved.
Saaybi, S., AlArab, N., Hannoun, S., Saade, M., Tutunji, R., Zeeni, C., . . . Rose-Mary Boustany.
(2019). Pre- and post-therapy assessment of clinical outcomes and white matter integrity in
autism spectrum disorder: Pilot study. Frontiers in Neurology, doi:10.3389/fneur.2019.0087
Benger, M., Kinali, M., & Mazarakis, N. D. (2018). Autism spectrum disorder: Prospects for
treatment using gene therapy. Molecular Autism, (1), 1. doi:10.1186/s13229-018-0222-8
Caputo, G., Ippolito, G., Mazzotta, M., Sentenza, L., Muzio, M. R., Salzano, S., & Conson, M.
(2018). Effectiveness of a multisystem aquatic therapy for children with autism spectrum
disorders. Journal of Autism & Developmental Disorders, 48(6), 1945-1956.
doi:10.1007/s10803-017-3456-y
DiPietro, J., Kelemen, A., Liang, Y., & Cecilia Sik-Lanyi. (2019). Computer- and robot-assisted
therapies to aid social and intellectual functioning of children with autism spectrum
disorder. Medicina, (8), 440. doi:10.3390/medicina55080440
Kaur, K. S., & Pathak, R. (2019). Play-based occupational therapy intervention on social skills in
children with autism spectrum disorder and attention deficit hyperactivity disorder: A case
series. Indian Journal of Occupational Therapy, 51(1), 31-36. doi:10.4103/ijoth.ijoth_5_19
© 2014. Grand Canyon University. All Rights Reserved.
Kenny, D. T. (2019). Faulty theory, failed therapy: Frances tustin, infant and child
psychoanalysis, and the treatment of autism spectrum disorders. SAGE Open,
doi:10.1177/2158244019832686
© 2014. Grand Canyon University. All Rights Reserved.
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